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3390/biomedicines10051006(IF:6
Before gel filling
Published 2021 Mar 17
axial skeletal malformations
MG132 (MG-132) _ 52801ES INF 3390/biomedicines10051006(IF:6MG132 is a potent, reversible, cell permeable proteasome inhibitor (IC50=100 nM), more than 1000 fold more potent than ZLLal in inhibiting the ZLLL MCA degradation activity of the 20S proteasome. MG132 also inhibits the cell cycle and calpain required for cyclin degradation (IC50=1. 2 M), and induces neurite outgrowth in PC12 cells. In addition, MG132 inhibited IB degradation, thereby inhibiting NF B pathway activation. MG132 induces apoptosis of MPM
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