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The higher avidity of CTLA-4 binding is primarily due to it very fast on-rate
** Please note: For orders over 1 mg
WQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQL
as well as Etanercept (Enbrel) which is a decoy protein consisting of the TNFR2 extracellular domain fused an Ig Fc region
Human B7-H3 Mouse IgG2a Wildtype Fc Amount:50 µg The higher avidity of CTLA-4B7 H3 is an orphan ligand in the B7 family. Its extended extracellular IgSF domain is unique within the family and is phylogenically found in primates only. B7 H3 is known as a co stimulatory and co inhibitory ligand, even though most studies indicate B7 H3 acts as an inhibitor for T cells functions. Consistent with the inhibitory notion, B7 H3 null mice exhibits an earlier onset of autoimmune disorders. P7105F contains all four extracellular IgV C
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