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Flayer of Loyalties also proves that WotC isn't quite done using the devastating Annihilator effect, which is good news for fans of old-school Eldrazi

Red White Angel Tribal - Anya Creature (14) 1x Admonition Angel 1x Aegis Angel 1x Angel of Jubilation 1x Angelic Skirmisher 1x Archangel of Tithes 1x Burnished Hart 1x Chancellor of the Annex 1x Emancipation Angel 1x Emeria Shepherd 1x Gisela, Blade of Goldnight 1x Guardian Seraph 1x Herald of War 1x Platinum Angel 1x Radiant, Archangel Land (37) Enchantment (9) 1x Brave the Sands 1x Gift of Immortality 1x Grasp of Fate 1x Luminarch Ascension 1x Manabarbs 1x Marshal's Anthem 1x Shielded by Faith 1x Spirit Mantle 1x Witch Hunt Artifact (18) 1x Assault Suit 1x Boros Cluestone 1x Boros Signet 1x Crawlspace 1x Darksteel Ingot 1x Hammer of Purphoros 1x Mind Stone 1x Moonsilver Spear 1x Norn's Annex 1x Seal of the Guildpact 1x Sol Ring 1x Staff of Nin 1x Swiftfoot Boots 1x Sword of the Animist 1x Thought Vessel 1x Thran Dynamo 1x Urza's Incubator 1x Wayfarer's Bauble Instant (15) 1x Boros Charm 1x Cloudshift 1x Deflecting Palm 1x Disenchant 1x Dispense Justice 1x Double Cleave 1x Faith's Reward 1x Make a Stand 1x Master Warcraft 1x Molten Influence 1x Otherworldly Journey 1x Rush of Blood 1x Shunt 1x Silence 1x War Flare Sorcery (6) 1x Defy Death 1x Mass Calcify 1x Overmaster 1x Planar Outburst 1x Righteous Confluence 1x Wrath of God

No, you cannot use channel with a card that is in play

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