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DBCO-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8)-PNP Size:50mg 68 SMILES Cl

SKU: 8215968486

4.4
USD445.00 USD492.00

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Description

68 SMILES Cl

297 SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)C2=CC(NCC#C)=CC=C12 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name DOTA-tris(t-Bu)ester-C2-propanamido-maleimide Synonyms CAS Number Related CAS Molecular Formula C37H63N7O10 Molecular Weight 765

while the para-aminobenzyl (PAB) spacer supports self-immolative release of the attached drug

DBCO-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8)-PNP Size:50mg 68 SMILES ClSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a DBCO Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to

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