HQ461 Size:5mg Cy3 alkyne

Cy3 alkyne

281 SMILES OCC#CC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

438 SMILES CC(C)(C)C1=CC=CC(OC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=C1 Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO

146 SMILES [2H]C([2H])([2H])OC1=CC=C(C(F)=C1)N(=O)=O Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

HQ461 Size:5mg Cy3 alkyneHQ461 is a molecular glue that promotes CDK12 DDB1 interaction to trigger cyclin K degradation. HQ461 mediated degradation of cyclin K impairs CDK12 function, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death. Product Name HQ461 Synonyms CAS Number 1226443 41 9 Related CAS Molecular Formula C15H15N5OS2 Molecular Weight 345. 44 SMILES CC1=CN=C(NC(=O)CC2=CSC(NC3=NC(C)=CC=C3)=N2)S1 Purity