Azide-Dap(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG4)-Exatecan Thalidomide CC0651 is an E2 enzyme

CC0651 is an E2 enzyme inhibitor

626 SMILES: CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC=C(C=C2C([O-])=O)C(=O)NCCCCCN)=[N+](C)C)=C1 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

94 SMILES ClCCOCCOCCOCCOCCOC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Its active site binds chloroalkane (CA)substrates

Azide-Dap(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG4)-Exatecan Thalidomide CC0651 is an E2 enzymeSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a Azide Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The azide functional group is widely utilized in bioconjugation via click chemistry to enable efficient and selective attachment of biomolecules. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further