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5 Purity (HPLC) >= 95% Solubility DMSO
[2H]C([2H])([2H])N(CCNC)C([2H])([2H])[2H] Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
Iberdomide promotes degradation of Aiolos and Ikaros proteins
Product Name Mal-Propiony-Beta-Ala-Gly-Gly-Phe-Gly-PAB(m-PEG8) Synonyms CAS Number Related CAS Molecular Formula C50H72N8O18 Molecular Weight 1073
Azide-Propionyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan dbco-hexanoyl 5 Purity (HPLC) >= 95%SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU
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