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SHP099 Size:5mg It is converted from 6-carboxytetramethylrhodamine

SKU: 5504729754

4.0
USD90.00 USD135.00

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Description

It is converted from 6-carboxytetramethylrhodamine (6-TAMRA) and has similar spectroscopic properties of 6-TAMRA

722 SMILES: [O-]C(=O)C1=CC(=CC=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)C(=O)NCCCN=[N]#N Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

Degrader building block for targeted protein degradation

Product Name Thalidomide-O-acetamido-C3-OH Synonyms Thalidomide-4'-O-acetamido-C3-OH CAS Number n/a Related CAS Molecular Formula C18H19N3O7 Molecular Weight 389

SHP099 Size:5mg It is converted from 6-carboxytetramethylrhodamineSHP099 is a highly potent (IC50 = 0. 071uM),selective and orally bioavailable small molecule SHP2 inhibitor. The inhibiting SHP2 activity of SHP099 is through an allosteric mechanism. SHP099 suppresses RASERK signalling to inhibit the proliferation of receptor tyrosine kinase driven human cancer cells in vitro and is efficacious in mouse tumour xenograft models. Product Name SHP099 Synonyms CAS Number 1801747 42 1 Related CAS Molecular Formula

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