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DBCO has been extensively used in copper-free click chemistry
Product Name MC-Gly-Gly-Phe-Gly-PAB(m-PEG8) Synonyms CAS Number Related CAS Molecular Formula C50H73N7O17 Molecular Weight 1044
Product Name DOTA-C2-propanamido-maleimide Synonyms CAS Number Related CAS Molecular Formula C25H39N7O10 Molecular Weight 597
411 SMILES OCCCCCCC1=CC=C2C(=O)N(CC2=C1)C1CCC(=O)NC1=O Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
Mal-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG4)-Exatecan Size:25mg DBCO has been extensively usedSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage
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