Propargyl-Acetyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE deuterium-labeled-amine 821 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])CCN(CC(O)=O)CC1 Purity (HPLC)

821 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name 6-FAM C2 maleimide Synonyms CAS Number N/A Related CAS Molecular Formula C27H18N2O8 Molecular Weight 498

N-(dimethyl-d6)aniline Synonyms CAS Number n/a Related CAS Molecular Formula C9H12ClN Molecular Weight 175

Fitzgibbons

Propargyl-Acetyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE deuterium-labeled-amine 821 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])CCN(CC(O)=O)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate