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403 SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)C2=C(NCCOCCOCC#C)C=CC=C12 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
Product Name Mal-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan Synonyms CAS Number Related CAS Molecular Formula C85H112FN11O27 Molecular Weight 1738
As a negative control
SHP099 is a highly potent (IC50 = 0
Mal-Propionyl-PEG8-Gly-Gly-Phe-Gly-PAB(m-PEG4) deuterium-labeled-amine 403 SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)C2=C(NCCOCCOCC#C)C=CC=C12 Purity (HPLC)SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG8 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. Derived from established ADC linker
