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Liljenberg
1039/d4cb00209a
148 Purity (HPLC) >= 95% Solubility DMSO
301 Purity (HPLC) >= 95% Solubility DMSO
Azide-Hexanoyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE dbco LiljenbergSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate
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