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Azide-Propionyl-Val-Cit-PAB(m-PEG8)-Exatecan Size:5mg piperidinyl)

SKU: 28745755106

4.6
USD445.00 USD467.00

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Description

piperidinyl)

5-ROX is the purified single isomer of 5(6)-ROX

The covalent linkage between the HaloTag ligand and HaloTag protein enables rapid isolation and purification

S)-AHPC-CO-C5-acid Synonyms CAS Number 2162120-87-6 Related CAS Molecular Formula C29H40N4O6S Molecular Weight 572

Azide-Propionyl-Val-Cit-PAB(m-PEG8)-Exatecan Size:5mg piperidinyl)SOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC

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