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Its also great alongside Indestructible creatures like Hazoret, Godseeker, since you get all the benefits but still keep your creature

Occasionally a cornerstone of Pioneer propping up a mono-green deck, any mono-colored deck that plays with devotion in mind can leverage Nykthos for an incredible mana advantage over their opponents

Even if it isn't an Ex card, Oricorio decks can be quite problematic for Greninja due to its Electric weakness, which can be harder to manage if the opponent also uses Magnezone from Space-Time Smackdown, as it can one-shot Greninja

You can do this to rebuy ETBs or help a creature dodge removal and stuff like that, but you can even just return a land if you just want the Familiar to be a 2/2